MRE11 and neuroblastoma: Inhibition of MRE11 by mirin, an inhibitor of its exonuclease activity discovered in 2008 [166], showed promising results in killing myeloma and neuroblastoma cell lines displaying high level of replication stress and endogenous DNA damages, evidenced by high amount of γ-H2AX and RAD51 foci as well high rate of ATR phosphorylation.