KMT2A and acute lymphoblastic leukemia: Although no other MLL-rearranged ALL specific agents could be identified, the top compounds in all three drug libraries appeared to be camptothecin and its derivatives 10-hydroxycamptothecin (10-HCPT), 7-ethyl-10-hydroxycamptothecin (SN-38) and topotecan (Figure 1f,g).