Finally, since invasion and metastasis are processes modulated by matrix metalloproteases (MMP) and their inhibitors TIMPs, we analyzed the effect of PTX and its conjugates on the mRNA expression of three genes known to participate in the migration and invasiveness of colon cancer cells., i.e., TIMP1, TIMP2 and MMP2 [26]. The gene discussed is TIMP2; the disease is malignant colon neoplasm.