ABCA1 may also be involved in inflammation through the regulation of the JAK2/STAT3 (Janus kinase 2/signal transducer and activator of transcription 3) pathway, which is connected by the IL-6 (interleukin-6) signaling pathway [80,81], which is a cytokine that is well known in the pathogenesis of COPD and atherosclerosis. This evidence concerns the gene STAT3 and chronic obstructive pulmonary disease.