In addition, in hepatoma cells, R777AB, LPA3 action is associated with the expression of genes related to drug resistance, such as Mdr (Multidrug resistance protein) 1a and 1b and Gstp1 (Glutathion-S-transferase pi 1) [15,77,78,79,80,81]. The gene discussed is GSTP1; the disease is hepatocellular carcinoma.