The most promising preparations acting on Eph include lithocholic acid derivatives (including UniPR126, which prevents EphA2 activation), salicylic acid derivatives (their potential to deliver other substances to Eph is mainly studied), green tea polyphenols, and their metabolites (their use is mainly limited by poor stability), doxazosin (a selective α1-adrenergic receptor inhibitor, which in mice studies has shown the ability to reduce prostate cancer metastasis and prolong survival) and peptide analogs mimicking the GH loop of ephrin [15]. This evidence concerns the gene EPHA1 and Familial prostate cancer.