Notably, multivariate Cox regression analyses revealed that the expression levels of five of those genes (CACNB2: p = 0.0189; IL34: p = 0.0425; CGNL1: p = 0.0014; CNTN3: p = 0.0304; and GAS7: p = 0.0412) were independent prognostic factors in patients with HNSCC (Figure 6). The gene discussed is CNTN3; the disease is head and neck squamous cell carcinoma.