Experiments with hLf demonstrated the further downregulation of 3-phosphoinositide-dependent protein kinase 1 (PDK1) transcription via mitogen-activated protein kinase/c-Jun pathway following deactivation of AKT signaling leading to inhibition of nasopharyngeal carcinoma (NPC) tumorigenesis [101]. The gene discussed is HLF; the disease is nasopharyngeal carcinoma.