Boncompagni et al. 2021: tubular aggregates (TAs) are abnormal accumulations of orderly disposed SR tubes which have been described in a variety of disorders [265,266,267,268,269,270], including TA myopathy (TAM), a disease recently linked to mutations in STIM1, ORAI1 [271,272,273,274,275,276], and CASQ1 [277]. This evidence concerns the gene ORAI1 and myopathy.