There were no significant differences of age, sex, the rates of liver cirrhosis, the rates of patients with HCC history, pretreatment platelet count, serum T-bil, AST, ALT, Alb, AFP, HCV RNA, M2BPGi levels, APRI, FIB-4 index, and resistance-associated substitutions between SVR cases and non-SVR cases. This evidence concerns the gene AFP and hepatocellular carcinoma.