PRKAA1 and obesity due to melanocortin 4 receptor deficiency: Other studies demonstrating that the stimulatory effect of thyroid hormones in BAT thermogenesis [65], WAT browning, and lipid metabolism are mediated by AMPKα1 attenuation in SF1 neurons [68] strongly support the notion that specific targeting of the discrete neuronal population in the VMH impacts obesity in a feeding-independent, but the thermogenic-dependent manner [56].