CFTR and cystic fibrosis: Aerosol delivery of the PB/AAVCFTR∆R in gut-corrected CF pigs resulted in correction of airway CFTR expression, transepithelial current, airway surface liquid pH, mucus viscosity and bacterial killing, thus providing proof that aerosol delivery of the shortened CFTR using the PB/AAVCFTR∆ vector can correct the CF phenotype in airways.