For example, Schildkopf et al. demonstrated in in vitro experiments on the human colorectal tumor cell lines HCT15 and SW480 and the mouse colon carcinoma cell line CT26-WT that temperatures above 41 °C in combination with radiotherapy resulted in significantly increased proinflammatory cytokine secretion (IL-8 and IL-12), and increased phagocytosis rates of macrophages and DCs compared with radiotherapy alone [27]. The gene discussed is CXCL8; the disease is colorectal neoplasm.