It is now well established MGMT expression is epigenetically silenced through promoter methylation in a large subset of brain tumors [11], and MGMT has emerged as one of the best-studied candidates for its susceptibility to cytosine-phosphate-guanine (CpG) island (CGI) for DNA methylation in glioma and other cancers [12,13]. Here, MGMT is linked to brain neoplasm.