However, the majority of GVHD mouse models are based on lethal total body irradiation (TBI) as a conditioning regimen, which is followed by either major histocompatibility complex (MHC)-mismatched or MHC-matched/minor histocompatibility antigen (miHA)-mismatched transplantation of bone marrow and (splenic or lymph node) T cells [13]. The gene discussed is HLA-C; the disease is graft versus host disease.