Recently, the involvement of CD147 in the pathogenesis of SARS-CoV-2 infection has been questioned, as Shilts et al. reported no interaction between host cell CD147 and recombinant SARS-CoV-2 Spike protein as well as no changes in the infection ability of the virus upon knock down of CD147 in lung cells [11]. The gene discussed is BSG; the disease is infection.