Altogether, our results support the previous finding that CD147 partakes in SARS-CoV-2 infection [6] at odds with Shilts and colleagues [11] and provide some additional clues on the underlying mechanism: (1) CD147 binding to CyPA does not play a role; (2) CD147 is involved in virus entry; (3) the two receptors might co-operate as they are co-regulated by viral infection and ACE2 levels are modulated by CD147 abundance. This evidence concerns the gene ACE2 and viral infectious disease.