Contrary to previous findings, ezrin was not identified in immunoprecipitated PODXL from SW1990 pancreatic cells, and PODXL knockdown failed to alter the activities of RhoA and Rac1, which are often induced by PODXL–ezrin binding; these results suggest that PODXL does not associate with ezrin in pancreatic cancer cells [18]. Here, EZR is linked to familial pancreatic carcinoma.