Breast cancer cell is known to produce numerous osteolytic factors, including parathyroid hormone-related protein (PTHrP), IL-1, IL-6, IL-8, IL-11, VEGF, connective tissue growth factor (CTGF), MMP1, HGF, etc. [86,87,88,89,90]. This evidence concerns the gene CXCL8 and breast carcinoma.