In an in vivo mouse model of breast cancer bone metastasis obtained with mice injected with COX-2-transfected MDA-435S cells, they isolated one-seeking clone from long-bone metastases that produces higher levels of PGE2 and correspondingly higher levels of IL-11 compared to COX-2-transfected parental MDA-435S cells. The gene discussed is IL11; the disease is breast cancer.