Additionally, we identified three genes in the limbic region which have not been reported in previous AD/MCI studies, including NOXRED1, MYL6B, and FAM162B. NOXRED1 (NADP–Dependent Oxidoreductase Domain–Containing 1 protein) is a key gene in oxidoreductase activity (Gene Ontology: 0016491). This evidence concerns the gene NOXRED1 and Alzheimer disease.