Three types of T-type calcium channels consisting of Cav3.1, Cav3.2, and Cav3.3 are encoded by CACNA1G, CACNA1H, and CACNA1I genes, respectively, which are expressed in the brain and play essential roles in both physiological and pathological systems, including sleep, pain, and epilepsy [13,14,15,16,17]. The gene discussed is CACNA1G; the disease is epilepsy.