The median level ± quartile deviation of CIAPIN1 level in the sera of CCA patient group was 0.5144 ± 0.34 μg/μL, which was significantly higher than 0.2427 ± 0.09 μg/μL of the HC group (p < 0.0001). The gene discussed is CIAPIN1; the disease is cholangiocarcinoma.