Macrophage-derived cytokines and chemokines including IL1β [124], CCL18 [125], and IL8 [126] can promote the epithelial-mesenchymal transition of pancreatic cancer cells through various signaling pathways, including PAR1 [127] and TLR4/IL10 activation [128]. Here, CXCL8 is linked to familial pancreatic carcinoma.