CDH1 and neoplasm: Another mechanism supporting the anticarcinogenic effect of quercetin is through downregulation of many cell cycle genes which cause cell cycle arrest, and suppression of tumor cell invasion and migration by regulating the expression of matrix metalloproteinases (MMPs), such as β-catenin [130], which can act as an invasion suppressor, and E-cadherin which is lost during tumor metastasis in association with the epithelial mesenchymal transformation [130].