The evaluation of the data from the quantitative real-time PCR assays also revealed, that while BMP-7 expression was significantly higher in the DPSC-BMP-7 cell line when cultured in the presence of doxycycline both in CM and OM, this increase did not significantly alter the expression of the differentiation marker Runx2 or the BMP antagonist noggin. The gene discussed is BMP7; the disease is ocular melanoma.