Specifically, in the case of cirrhotic patients, a reduced SPIR clearance from the central compartment (i.e., CL) by ~85%, metabolic clearance (i.e., CLM1) by ~38%, and CAN clearance from the central compartment (i.e., CLM) by ~72% were considered to reproduce the much longer half-lives observed in adult cirrhotic subjects [17] and may be considered to reproduce the same magnitude of changes in pediatric subjects (additional information provided in the Supplementary Materials on the considerations used to simulate the scenarios in adult patients with liver cirrhosis). This evidence concerns the gene CD300LF and cirrhosis of liver.