Nonetheless, the improvement of spatial learning and memory arises in supplemented rodent models of pathological conditions, such as the APP/PS1 mice model of Alzheimer’s disease [26,27,28], the Ts65Dn mice model of Down’s syndrome [39,42], traumatic brain injury [58], impoverished environment [63] and seizure inducing doses of pilocarpine [69] or kainic acid [48,66]. Here, APP is linked to early-onset autosomal dominant Alzheimer disease.