Choline supplementation that improved performance in the water maze, attentional and emotionality/anxiety tasks partially prevented the reduced number and abnormalities of basal forebrain cholinergic neurons, increased the amygdala and hippocampal cholinergic innervation and ameliorated amyloid pathology in APP/PS1 mice correlating the brain changes with better behavioral performance [26,27,28,35]. Here, APP is linked to Anxiety.