The human mAb, Nivolumab, recognizes the Programmed Death receptor-1 (PD-1), that is expressed on T-cells where it exerts a crucial role in immune suppression [3,4] upon its binding to its natural ligand, Programmed Death Ligand 1 (PD-L1), which is expressed on Antigen Presenting Cells (APC) and on cancer cells [5]. Here, CD274 is linked to cancer.