In particular, PD-L1_1 and 10_12 mAbs were found to inhibit the phosphorylation levels of Erk, P38 and JNK in SKBR-3 and CT-26 tumor cells, whereas Ipilimumab and ID-1 increased the phosphorylation of Erk in NK cells. This evidence concerns the gene MAPK8 and neoplasm.