KRAS and malignant colon neoplasm: Based on the genes that were specifically up-regulated in BRAF mutant CRC in comparison with BRAF and KRAS wild-type CRC, Vecchione et al. [6] were able to identify spindle formation and mitotic progression as distinct druggable features of BRAFV600E mutant colon cancer cells and revealed the ability of vinorelbine, a vinca alkaloid that prevents formation of the mitotic spindle, to selectively suppress the growth of BRAF-mutated colon cancer cells both in vitro and in vivo.