Starting initially from the list of differentially expressed proteins with a significantly increased abundance in the BRAF mutant colon cancer cell line, we retrieved the enriched protein–protein interaction dataset from the DAVID online functional annotation tool, which was then uploaded into STRING to finally construct the PPI network consisting of 235 nodes and 641 edges, with a confidence score of 0.900 and an average local clustering coefficient of 0.546 (PPI enrichment p-value < 1.0 × 10−16) (Figure 2). Here, BRAF is linked to malignant colon neoplasm.