Depletion of RANBP2 in BRAFV600E mutant colon cancer cells impaired spindle formation and prolonged mitosis, ultimately inducing cell death, which led the authors to hypothesize that BRAF mutant colon cancer cells could be sensitive to microtubule-disrupting agents such as vinorelbine, and this presumption was indeed confirmed in vitro and in vivo [6]. Here, RANBP2 is linked to malignant colon neoplasm.