Inhibition of the nucleophosmin function by NSC348884 in vemurafenib-resistant colon cancer cell lines with a BRAF mutation potentiated the cytotoxic effects of vemurafenib in a concentration- and time-dependent manner, regardless of the p53 status, to an extent that was not observed with c-Myc inhibition. This evidence concerns the gene TP53 and malignant colon neoplasm.