Since many of these proteins including NPM1 [13], RanBP1 [14], eIF4E [15] and PSPH [16] were previously reported to be transcriptional targets of c-Myc, expression of c-Myc in colon cancer cell lines differing in their BRAF mutational status was also examined. The gene discussed is EIF4E; the disease is malignant colon neoplasm.