Next, we analyzed the mRNA expression profiles of selected targets in BRAF mutant colon cancer in The Cancer Genome Atlas (TCGA) colon adenocarcinoma cohort using cBioPortal and found that only the NPM1 mRNA expression level was significantly increased (p = 0.0498) in BRAFV600E mutant colon cancer in comparison with WT BRAF (Figure 4). The gene discussed is NPM1; the disease is malignant colon neoplasm.