Importantly, we detected significantly stronger nuclear and, in particular, cytoplasmic staining of phospho-NPM1 (Thr199) in tumor tissue specimens from BRAFV600E-mutated in comparison with KRAS mutant/BRAF wild-type and double wild-type KRAS/BRAF colonic adenocarcinomas using immunohistochemistry. The gene discussed is NPM1; the disease is colon adenocarcinoma.