Our results are partially in accordance with these findings by revealing that inhibition of c-Myc transcription by IZCZ-3 selectively induced a marked increase in the response to vemurafenib in BRAFV600E mutant colon cancer cells carrying wild-type p53, which suggests that the chemosensitizing effect of c-Myc inhibition might be governed by the functional status of the p53 gene. This evidence concerns the gene MYC and malignant colon neoplasm.