BRAF and colon adenocarcinoma: Next, we analyzed the mRNA expression profiles of selected targets in BRAF mutant colon cancer in The Cancer Genome Atlas (TCGA) colon adenocarcinoma cohort using cBioPortal and found that only the NPM1 mRNA expression level was significantly increased (p = 0.0498) in BRAFV600E mutant colon cancer in comparison with WT BRAF (Figure 4).