Similar to our findings, a previous study also identified mitosis as a potential vulnerability of BRAFV600E-mutated colon cancer cell lines by revealing RANBP2 as the gene indispensable for survival of BRAFV600E colon cancer cell lines with no effects on the viability of wild-type KRAS/BRAF colon cancer cells [6]. Here, RANBP2 is linked to malignant colon neoplasm.