In parallel, we found that the proportions of CD4+ T cells and CD8+ T cells in the spleens were elevated by chemotherapy though not in a significant manner (Figure 7(B1)); yet, the increased levels of these two subsets following chemotherapy were significantly correlated with reduced tumor growth (Figure 7(C2,C3)), suggesting that chemotherapy affected CD4+ and CD8+ T cells in the direction of anti-tumor phenotypes. This evidence concerns the gene CD4 and neoplasm.