The above findings indicated that whereas the CD4+ TNFR2+ FOXP3+ and the CD4+ TNFR2+ PD-1+ TIL subsets were connected to high tumor growth in the absence of chemotherapy treatment, the CD8+ TNFR2+ and particularly the CD8+ TNFR2+ PD-1+ TIL subsets were linked to the inhibition of tumorigenicity in 4T1 tumors when the mice were treated using chemotherapy. This evidence concerns the gene CD4 and neoplasm.