We found it particularly important that the ratio of CD8+ TNFR2+ PD-1+ TILs over either of these two subsets of CD4+ TNFR2+ TILs (CD4+ TNFR2+ FOXP3+ and CD4+ TNFR2+ PD-1+) was significantly increased in chemotherapy-treated mice and was strongly connected to reduced tumor volumes. The gene discussed is CD8A; the disease is neoplasm.