CD4 and neoplasm: The data indicate that a chemotherapy-induced up-regulation of CD8+ TNFR2+ and CD8+ TNFR2+ PD-1+ TILs at the expense of CD4+ TNFR2+ FOXP3+ TILs and CD4+ TNFR2+ PD-1+ TILs was connected to reduced tumor growth, possibly through alteration in anti-tumor immune activities.