Additionally, in another recent meta-analysis, Borsetto et al. [37] investigated the prognostic role of CD4+ and CD8+ T cells in HNSCC, and found a significant reduction in the risk of death for both high CD4+ and CD8+ lymphocytes in oropharyngeal and for CD8+ TILs in hypopharyngeal cancers. This evidence concerns the gene CD4 and head and neck squamous cell carcinoma.