In MYC-driven medulloblastoma, the combination of AZD1775, an inhibitor of the cell cycle checkpoint kinase WEE1, with gemcitabine, an antimetabolite that attenuates nucleotide synthesis and promotes replicative DNA damage, significantly increased cytotoxic DNA damage and resulted in full regression of murine tumor xenografts [114]. The gene discussed is MYC; the disease is neoplasm.