VWF and COVID-19: Endotheliopathy is at the core of COVID-19 pathophysiology, as evidenced by the increased circulating levels of various biomarkers of endothelial injury, including von Willebrand factor, angiopoietin2, thrombomodullin [72], endothelial-derived extracellular vesicles [85], and endothelial progenitor cells [86], whose levels directly correlate with the severity of COVID-19 [72,79].