In addition, the antiangiogenic activity of fucoidan was confirmed in MDA-MB-231 cells through the reduction of VEGFA, IGF-I, MMP-2, and MMP-9 levels, basic fibroblast growth factor (bFGF), and the blockade of the adhesion and extravasation of tumor tissue to vascular endothelial cells. This evidence concerns the gene IGF1 and neoplasm.