Generally, miR-373-3p acts as a potent proto-oncogenic factor in tongue squamous cell carcinoma (TSCC), and upregulation of miR-373-3p leads to the promotion of TSCC invasion via activation of Wnt signaling by the downregulation of Dickkopf-1 (DKK1) [20]. This evidence concerns the gene DKK1 and tongue squamous cell carcinoma.