Tosoian et al., evaluated it in a cohort of men with favourable-risk PCa included in AS programs and who underwent tumour reclassification, demonstrating that patients who reclassified had significantly higher PCA3 scores at both initial (48.0 vs. 24.5, p = 0.007) and subsequent (63.5 vs. 36.0, p = 0.002) measurements, indicating an association between PCA3 and grade reclassification [65]. This evidence concerns the gene PCA3 and posterior cortical atrophy.