For this reason, it can be employed as a model of neurodegenerative-disease-connected tau hyperphosphorylation, a well-known feature of Alzheimer’s disease, but present also in other NDDs, collectively known as tauopathies and characterized by the pathological aggregation of hyperphosphorylated tau in neurofibrillary tangles. The gene discussed is MAPT; the disease is Alzheimer disease.