MAPT and early-onset autosomal dominant Alzheimer disease: For this reason, it can be employed as a model of neurodegenerative-disease-connected tau hyperphosphorylation, a well-known feature of Alzheimer’s disease, but present also in other NDDs, collectively known as tauopathies and characterized by the pathological aggregation of hyperphosphorylated tau in neurofibrillary tangles.