In addition, the overexpression of miR-155 exerts antitumoral properties, characterized by increased expression of TNF-α (tumor necrosis factor α), IL-12 and NOS2 expression, as well as a reduction in IL-10, arginase-1 and IL-22 in conditioned culture medium from tumor-associated macrophages (TAMs) [100] (Figure 3A5). This evidence concerns the gene NOS2 and neoplasm.