A model of risk has been constructed according to the expression data of methyltransferase-like protein 6 (METTL6), RNA polymerase III subunit G (POLR3G), phosphoribosyl pyrophosphate amidotransferase (PPAT), SETDB2 and SUV39H2 in 352 HCC patients, obtained from The Cancer Genome Atlas Liver Hepatocellular Carcinoma database. This evidence concerns the gene PPAT and hepatocellular carcinoma.