CDKN2A and hepatocellular carcinoma: Moreover, Lee et al. [35] suggested that the CpG island hypermethylation of cox-2 or p16 might be potential molecular markers for the identification of HCC, and also that the CpG island hypermethylation of e-cadherin or gstp1 might be used as a potential biomarker for the prognostication of HCC.