Furthermore, other studies have shown that hypermethylation of ER, MYOD, CDKN2A (encoding p16) and BVES could also be detected in the non-dysplastic tissues from patients with UC with progressive neoplasia compared to non-progressors [192,193], providing further evidence of an epigenetic field cancerisation effect. The gene discussed is CDKN2A; the disease is neoplasm.