Mutational panels of key driver genes such as TP53, APC, KRAS, CDKN2A and FBXW7 [136,144,162,163] have also been suggested, but whilst a mutation in one of these genes may not be able to differentiate a S-CRC from CA-CRC, a mutation of one of the above found from dysplastic tissue in a patient with UC still might be able to predict CA-CRC occurrence [164,165]. Here, APC is linked to colorectal carcinoma.