Although targeted mutational analysis of sDNA (TP53, APC, KRAS, BRAF or PIK3CA) failed to discriminate CA-CRC samples from cancer-free IBD (n = 50), the methylation of four genes (vimentin, EYA4, BMP3, NDRG4), distinguished patients with UC; with or without neoplasia, suggesting both high specificity and sensitivity for dysplasia detection [223]. Here, APC is linked to cancer.