Watanabe et al. [182] also identified 20 genes showing differential expression in CA-CRC (n = 10) and UC control patients (n = 43), which included cancer-related genes such as CYP27B1, RUNX3, SAMSN1, EDIL3, NOL3, CXCL9, ITGB2 and LYN. Specific roles for TIMP1, ZEB1 and CD133 expression have also been proposed in the development of progressive disease [183,184,185]. The gene discussed is ITGB2; the disease is cancer.