CD8A and colorectal carcinoma: Recent work also suggests an essential role for immune evasion in the transition to malignancy in S-CRC [228,229], whilst Galon et al. [230] have also demonstrated that an ‘Immunoscore’ that quantifies the CD3+ and CD8+ immune infiltrate of a CRC held more prognostic significance than the currently used AJCC/UICC TNM classification.