TP53 and cancer: Galandiuk et al. [144] demonstrated how a ‘cancer primed’ phenotypically non-malignant region can progress to CA-CRC by describing one case where at least 3 separate TP53 mutations arose in non-neoplastic colon, each of which gave rise to neoplastic lesions several years later, with the most recently detected TP53 mutant spreading over 3 years to involve the entire length of the colon.