PHOX2B and neuroblastoma: Relying on the SE profiles, both studies demonstrated that neuroblastoma cells may adopt two distinct identities consistent with the previous phenotypic observations: a neuronal sympathetic identity associated with SEs and expression of adrenergic/noradrenergic markers such as PHOX2B, TH, and DBH or an undifferentiated identity, closely resembling NCC lines, associated with SEs and expression of mesenchymal markers such as vimentin or fibronectin (Figure 1C).