PHOX2B and colorectal carcinoma: Importantly, GATA3−/− clones showed a strong reduction in the expression of the TFs of the NOR CRC, including PHOX2A, PHOX2B, and HAND2 [29], and bulk RNA-seq analysis showed that these cells exhibited a mesenchymal transcriptomic profile, as they were close to the SH-EP cell line.