Sato et al. examined 497 patients with myositis-related ILDs in the JAMI (Japanese patients with myositis-associated ILD) study and found that poor prognostic factors in multivariate analysis included: (1) onset at 60 years or older; (2) anti-MDA5 antibody positivity; (3) C-reactive protein (CRP) > 1 mg/dL; and (4) SpO2 <95% [51]. Here, IFIH1 is linked to myositis disease.