These chemokines and cytokines have the capacity to affect recruitment of different immune cells, such as cytotoxic CD8+ T cells (CTLs), T helper (Th) cells, and T regulatory cells (Tregs)), tumor-associated macrophages (TAMs), myeloid derived suppressor cells (MDSCs), and tumor-associated neutrophils (TANs) [26]. The gene discussed is CD8A; the disease is neoplasm.