Conversely, another subtype of CAF includes the inflammatory CAF (iCAF), which has immunosuppressive and immunogenic functions and leads to the secretion of many cytokines and chemokines that are inflammatory in nature, such as inteleukin-6 (IL-6) and chemokine (C-X-C) motif ligand 12 (CXCL12), as well as supportive of tumor progression [16,19]. This evidence concerns the gene CXCL12 and neoplasm.