EGFR and colorectal cancer: Although several combinations with RTK inhibitors have been proposed, only targeting of ErbB family members is being tested in clinical trials, including a pan-ErbB or EGFR inhibitor (CodeBreak 101), cetuximab or afatinib (KRYSTAL-1) and cetuximab versus chemotherapy in the phase III KRYSTAL-10 trial in pre-treated colorectal cancers.