Further, the functional significance of DNASE1L3 expression in ECs has not been explored, but it may indeed be very relevant given the strong genetic associations connecting DNASE1L3 to the development of anti-dsDNA antibodies and various autoimmune phenotypes including lupus [96,97,101], systemic sclerosis [102], scleroderma [96,101], and hypocomplementemic urticarial vasculitis syndrome [103]. Here, DNASE1L3 is linked to systemic lupus erythematosus.