In a different mouse model of AD, in a transgenic 5xFAD mouse, it was found that iso-α-acids ameliorated the pro-inflammatory cytokine production, increased microglial phagocytosis of the β-amyloid peptides, prevented tau phosphorylation and tauopathy, and induced the improvement in both memory and cognitive function [61,62,63]. Here, MAPT is linked to Alzheimer disease.