FENDRR and melanoma: We also assessed the role of FENDRR overexpression on Wnt signaling in B16F10 melanoma cells because it is highly expressed in malignant melanoma, drives metastasis by regulating mitochondrial activity in a PTEN-dependent manner, and enhances the formation of vasculogenic mimicry and linearly patterned programmed cell necrosis [22,23,25].