Pathological angiogenesis is involved in many diseases, including cancer [4,5,6], metastasis [7], obesity [8,9], joint synovial neovascularization secondary to rheumatoid arthritis [10,11], enlargement of existing vessels in papillary dermis secondary to psoriasis [12], persistent hyperplastic vitreous syndrome due to genetic loss of angiopoietin-2 (Ang-2) [13], plaque angiogenesis in atherosclerosis [14], asthma [15], preeclampsia [16], COVID-19 [17,18] and eye diseases [19]. This evidence concerns the gene ANGPT2 and obesity due to melanocortin 4 receptor deficiency.