Antiangiogenic intravitreal injections, even when performed under sterile conditions, present a risk of endophthalmitis, intraocular inflammation, vitreous hemorrhage, retinal detachment, intraocular pressure elevation, subconjunctival hemorrhage and chorioretinal atrophy, since VEGF is a pro-survival factor [199,200]. The gene discussed is VEGFA; the disease is endophthalmitis.