However, a metabolomic screen of hPheo1 pheochromocytoma cells and SDHB knockdown hPheo1 cells together with cancer tissues with and without SDHx mutations revealed that the polyamines spermidine and spermine were significantly elevated in relation to mutated succinate dehydrogenase. Here, SDHB is linked to hereditary pheochromocytoma-paraganglioma.