PDCD1 and hepatocellular carcinoma: Results demonstrated that intratumoral and peritumoral neutrophils had increased levels of PD-L1 expression compared to circulating neutrophils in patients with HCC, providing evidence that TANs had strong immunosuppressive effects in these patients and highlighting the potential role of PD-L1+ neutrophils as targets of anti-PD-1 and/or anti-PD-L1 antibodies in order to reverse their immunosuppressive phenotype [45].