In addition, another study by Li et al. provided evidence that the majority of neutrophils in HCC intratumoral regions expressed autophagy specific protein LC3 and autophagosomes, while neutrophil autophagy was also correlated with sustained production of pro-metastatic oncostatin M and MMP9 and advanced migration of cancer cells [57]. This evidence concerns the gene MMP9 and hepatocellular carcinoma.