In a study, Zhou et al. suggested that Chemokine (C-X-C motif) ligand 5 (CXCL5) mediated the infiltration of neutrophils and subsequent HCC cell differentiation and invasion and that CXCL5 overexpression, alone or in combination with intratumoral neutrophil presence, acted as a prognostic indicator for overall survival (OS) [54]. This evidence concerns the gene CXCL5 and hepatocellular carcinoma.