CYLD and hepatocellular carcinoma: In the HCC microenvironment, TANs secrete bone morphogenetic protein 2 (BMP2), TGF-β2 and trigger miR-301b-3p expression in HCC cells, subsequently suppressing gene expression of limbic system–associated membrane protein (LSAMP), cylindromatosis lysine-63 deubiquitinase (CYLD) and as a consequence increase the stem cell-like characteristics of HCC cells.