In patients with HS, the ALT (39.1 ± 28.1 U/L vs. 26.9 ± 18.3 U/L, p = 0.003), triglyceride (197.1 ± 95.3 vs. 121.6 ± 51.4 mg/dL, p < 0.001), insulin (44 ± 52 mcIU/mL vs. 17.3 ± 14.2 mcIU/mL, p < 0.001) and HOMA-IR (13.1 ± 18.1 vs. 3.9 ± 3.5, p < 0.001) levels were significantly higher in comparison with patients without HS whereas HDL (39 ± 8.4 mg/dL vs. 50.6 ± 14 mg/dL, p = 0.001) levels were significantly lower. The gene discussed is GPT; the disease is histiocytic sarcoma.