PAFAH1B1 and lissencephaly spectrum disorders: Several other compounds are under investigation for their activity over microtubules and microtubule-related proteins, e.g., blood–brain barrier-penetrant heterocyclic molecules able to stabilize microtubules, and calpain inhibitors, which, by protecting the protein LIS1 (platelet-activating factor acetylhydrolase 1b regulatory subunit 1) against proteolysis, are able to recover retrograde transport and network formation in LIS1+/- mice (a model of lissencephaly) [415,416].