BMAL1 and Cognitive impairment: Moreover, mice deficient for ARNTL (aryl hydrocarbon receptor nuclear translocator like, also known as Bmal1), an essential component of the molecular clockwork driving circadian rhythms, showed severe cognitive deficits, associated with a reduction of perisynaptic astrocytic processes covering hippocampal mossy fiber synapses, which is probably due to a reduction of RHOA activity in Arntl-deficient astrocytes [327].